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safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in hiv-positive men and women elizabeth a stier , 1 stephen e. Darragh , 7 maria da costa , 4 lori panther , 8 david aboulafia , 9 and joel m. Onset of cidofovir therapy post tx indications pretreatment mode of cidofovir application duration of therapy switch to sirolimus response recurrence secondary treatment 1 ha heart february 2002 32 m no 2 years anal condylomata surgery, imiquimod injection 1 setting no yes yes surgery, imiquimod 2 mm kidney january 2001 30 m yes 2. an application to approve the use of topical cidofovir for acyclovir- resistant herpes virus infection was denied by the fda owing to the lack of phase iii data. Cidofovir anhydrous is an anhydrous form of cidofovir, a synthetic, acyclic monophosphate nucleotide analog of deoxycytidine with antiviral activity, mostly used against cytomegalovirus (cmv). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides. For localized lesions such as anal or penile condylomata injection was used, whereas for widespread hpvassociated warts and for the hand recipient it seemed reasonable to use cdv gel. In terms of intervals of application and cdv concentration of the gel, for the two patients with widespread verrucae vulgares we initially used the 5 gel. Clinical responses to cidofovir applied topically to women with high grade vulval. High-grade vulval intraepithelial neoplasia (vin 3) a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell. Request pdf treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome.