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There is a rich history of the use of natural products in the treatment of parasitic diseases, including malaria. Mushrooms have been used for nutritional and medicinal purposes since ancient times. The mushroom agaricus blazei is of brazilian origin and has been used as a functional food and a popular medicine. We used animal models of dm types 1 and 2 and found that both models mice displayed a significant increase in bgl vs control counterparts, mimicking hyperglycemia in dm patients34,35. Dm mice exhibited memory decline, confirmed by two well-established tests, y-maze and mwm23,24.   end organ injury in diabetes mellitus (dm) is driven by microvascular compromise (including diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication of dm types 1 and 2 however, its mechanism(s) is(are) not known. We hypothesized that blood-brain barrier (bbb) compromise plays a key role in cognitive decline in dm. The computation of non-dominated alternatives with incomplete information is constructed with a tool developed for the models introduced in this study. The implemented tool computes the aluesv of di erent alternatives and nds the non-dominated alternatives. However, we will verify several identities involving pfaffians carefully (for instance, lemmas 3.).   citrulline is a non-protein amino acid, and in humans its plasma content is derived largely from the amount produced in enterocytes of the small bowel. 1 citrullines first isolation from the juice of the watermelon has been attributed to koga and ohtake 2,3 and wada. 4 certain clinical conditions have been identified in which citrulline has been used as a marker of intestinal function.   serotonin depletion and inactivation has been shown to impair cognitive flexibility (clarke et al. , 2017) and there is evidence that this may be due to decreased basal activation of 5-ht2ars (boulougouris et al.). Intracranial self-stimulation (icss) is an operant behavioral paradigm in which experimental animals learn to deliver brief electrical pulses into specific regions of their own brains that are considered to be part of the brains reward pathways mediating both natural and icss reward. , interpolation of analytic functions of moderate growth in the unit disc and zeros of solutions of a linear dif-ferential equation, j.

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